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in these placebo-controlled studies of 665 doxazosin patients, treated for a mean of 85 days, additional adverse reactions have been reported.
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there also was no evidence of carcinogenicity in a similarly conducted study in mice receiving oral doxazosin for up to 18 months; however, the relevance, if any, of the findings of this study in mice is unclear since the maximally tolerated dosage was not employed.
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similarly, the relative efficacy of doxazosin 1 to 16mg once daily and hydrochlorothiazide 25 to 100mg once daily remains to be clarified.
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