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Generic copegus ribavirin is an antiviral medication used to treat a variety of infections.

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Substantial increases in ribavirin plasma concentrations are seen in patients with serum creatinine 2 mg dl or with creatinine clearance 50 ml minute, therefore copegus dose adjustments are recommended in these patients see sections 4.

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In patients with esrd on chronic haemodialysis and who received 200 mg daily doses of copegus, mean ribavirin exposure auc was found to be approximately 20 lower compared to patients with normal renal function receiving the standard 1000 1200 mg copegus daily dose.

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